Persons with acquired brain injury often experience changes in physical functioning and mobility, ability to carry out activities of daily living, cognitive-linguistic skills, leisure participation and ability to engage in productive activities. These changes frequently prevent community integration, limit the ability to engage in meaningful daily activities and restrict participation in meaningful life roles. Rehabilitation is a systemic, evidence-based attempt to improve functioning in all life domains through remediation, compensation, use of adaptive equipment and environmental modification. The ultimate goal of rehabilitation is to reduce the impact of activity limitations and participation restrictions on the person with brain injury so they may live with the greatest degree of independence and life satisfaction possible. During the rehabilitation process and beyond, persons with acquired brain injury deserve to be treated with dignity and respect, in a way that honors their age, recognizes their life experience and considers family and cultural influences. Throughout the rehabilitation process, persons with acquired brain injury should be provided with appropriate alternatives and given the opportunity to make informed choices. They should be allowed to risk with appropriate supports. Staff delivering rehabilitation services should be creative and flexible using multiple modalities to meet individual needs. An interdisciplinary team approach appears to be the most appropriate vehicle by which to meet the multiple and complex issues of acquired brain injury.